Medical OSCES

Medical OSCES for medical students and PG Doctors

Menu
  • Home
  • Static Page
  • Radiology Cases
    • Neurology
    • Peadiactric
    • Chest
    • GIT
    • GUT
  • Radiology Notes
    • Neurology
    • Peadiactric
    • Chest
    • GIT
    • GUT
  • Lectures
    • Radiology
    • Anatomy
    • Physics
    • Radiography
  • Videos
  • Books
  • Surprise Me
Dermatology A 37-year-old man received a bone marrow transplant

A 37-year-old man received a bone marrow transplant

Acute Graft-Versus-Host Disease

A 37-year-old man received a bone marrow transplant 2 weeks previously for acute myelogenous leukemia. Two days ago, itching, diarrhea, pain and numbness in his palms and soles, and the skin lesions shown here developed. Each of the following statements about this condition is true except:

a. Use of HLA-identical grafts eliminates the risk of this condition
b. This condition typically occurs 7 to 21 days after transplantation
c. Increased age is a risk factor for this condition
d. Sex mismatch (female donor, male recipient) is a risk factor for this condition
e. Values on liver function tests are often increased in this condition

 


Acute Graft-Versus-Host Disease

Answer: a
• Occurs 7 to 21 days after transplantation
• Donor T cells attack host HLA antigens
• Mean frequency in adults with HLA-identical grafts is 35%
• Risk factors include the following:


Increased age
HLA mismatch
Sex mismatch (female donor, male recipient)
Irradiation
Suboptimal immunosuppression


• Affects the skin, gastrointestinal tract, and liver
• Pruritus and pain may be the first sensations, commonly followed by an erythematous measles-like maculopapular exanthem. Acral erythematous lesions may develop on palms, soles, and ears
• Blistering and exfoliation are common
• Digestive tract involvement may present (from less severe to more) as nausea, vomiting, anorexia, diarrhea, malabsorption, abdominal pain, ileus, and ascites
• Values on liver function tests are often increased; jaundice and hepatomegaly may develop
• Treatment involves intensifying immunosuppression, such as high-dose corticosteroids, cyclosporine, and cyclophosphamide
• Severe cases (grade IV) have a high mortality rate (>80%)


Dermatology
  • Tweet
  • Share
  • Share
  • Share
  • Share

Related Posts

Total Tayangan Laman

  • …

  • …

Weekly Posts

  • A 23-year-old man after  motor vehicle accident
    A 23-year-old man after motor vehicle accident
    This 23-year-old man was involved in a motor vehicle accident. What is the diagnosis? Aortic dissection Cardiac rupture Diaphragmatic rup...
  • Name the arrowed structure ?
    Name the arrowed structure ?
    Left Ventricle
  • After a short period of fever and malaise,patient develops pain in a dermatome,followed by appearance of lesion in the same dermatome,
    After a short period of fever and malaise,patient develops pain in a dermatome,followed by appearance of lesion in the same dermatome,
      1.What’s the lesion? 2.What’s the causative agent ? 3.What are the complications of this condition? 4.How would you treat?
  • Diffuse Axonal Injury
    Diffuse Axonal Injury
    Findings: Diffuse brain swelling Focal punctate hemorrhage scattered in the white matter, corpus callosum, and brain stem Right subgaleal...

Label

  • Cardiology (12)
  • Chest x-ray (9)
  • CT Scans (6)
  • Dermatology (56)
  • ECG (2)
  • Endocrinology (10)
  • ENT (2)
  • Gastroenterology (15)
  • Genetics (6)
  • Gyn and Obs (5)
  • gynaecology (4)
  • Haematology (17)
  • Image Challenge (214)
  • Immunology (3)
  • infectious and parasitic disease (3)
  • Infectious disease (5)
  • Instruments (1)
  • Microbiology (2)
  • Musculoskeletal (3)
  • NEJ Cases (9)
  • Nephrology (2)
  • Neurology (15)
  • oncology (3)
  • Ophthalmology (13)
  • Orthopaedic (8)
  • Parasitology (4)
  • Peadiactrics (12)
  • Pediatric EMCQ (1)
  • Pediatric EMCQs (5)
  • Pharmacology (4)
  • Pulmonology (9)
  • Radiology (30)
  • Real Cases (5)
  • Rheumatology (7)
  • Skull X-ray (2)
  • Surgery (4)
  • Vascular surgery (1)
  • x-ray (6)

Contact

Name

Email *

Message *

Copyright © 2014 Medical OSCES All Right Reserved
Blogger Templates Created by Arlina Design